What Is Genome-Wide Association Study (GWAS)?

GWAS is a method for the study of associations between a genome-wide set of single-nucleotide polymorphisms (SNPs) and desired phenotypic traits. The quantitative evaluation is based on linkage disequilibrium (LD) through genotyping and phenotyping of diverse individuals. Generally, a GWAS infers these associations through a hypothesis test with pertinent test statistics such as Pearson’s x2 -test, Fisher’s exact test, the F-test, or a regression model under a null hypothesis assumes no association.

As a result of continuously dropping cost for DNA sequencing, whole genome sequencing has been largely available in a wide range of species with phenotype variations, promoting the application of GWAS.

What Is Genome-Wide Association Study (GWAS)?