What Is Genome-Wide Association Study (GWAS)?

GWAS is a method for the study of associations between a genome-wide set of single-nucleotide polymorphisms (SNPs) and desired phenotypic traits. The quantitative evaluation is based on linkage disequilibrium (LD) through genotyping and phenotyping of diverse individuals. Generally, a GWAS infers these associations through a hypothesis test with pertinent test statistics such as Pearson’s x2…

Co-immunoprecipitation (Co-IP) Assay

The Co-IP assay is a powerful technique that is widely used for the discovery and detection of protein-protein interactions. The principle of this technology is to utilize the antigen-antibody interaction to pull-down putative interactive partners of the target protein. Specifically, the antibody of the target protein is immobilized in affinity resins, which are then exposed…